The 2021 División Intermedia season, named "Cincuentenario del Club Atlético 3 de Febrero y Homenaje al Lic. Miguel Ángel Cañete Alderete", was the 103rd season of the second-tier league of Paraguayan football and 24th under the Paraguayan División Intermedia name. The season began on 9 April and ended on 26 October 2021. The fixtures for the season were announced on 15 January 2021. The competition returned after a one-year hiatus as the 2020 seasons of the lower-tier club tournaments of Paraguayan football were cancelled by the Paraguayan Football Association due to the COVID-19 pandemic.