The Amazeen House is an historic house at 15 Weeks Street in Houlton, Maine, United States. This imposing 2+1⁄2-story Italianate house was built c. 1882 as a speculative venture, probably intended for use as a hotel, based on the projected route of the New Brunswick Railway. It is one of Houlton's most impressive 19th-century houses, and was listed on the National Register of Historic Places in September 1986.