The 2020–21 High Point Panthers men's basketball team represented High Point University in the 2020–21 NCAA Division I men's basketball season. The Panthers, led by third-year head coach Tubby Smith, played their home games at the Millis Athletic Convocation Center in High Point, North Carolina, as members of the Big South Conference. This was the Panthers' final season at the Millis Center, with the new Qubein Center opening for 2021–22.