The 2021–22 Southern Combination Football League season was the 97th in the history of the competition, which lies at levels 9 and 10 of the English football league system. The provisional club allocations for steps 5 and 6 were announced by The Football Association on 18 May. After the abandonment of the 2019–20 and 2020–21 seasons due to the COVID-19 pandemic, a number of promotions were decided on a points per game basis over the previous two seasons.