The 2021–22 Syed Mushtaq Ali Trophy was the fourteenth season of the Syed Mushtaq Ali Trophy, a Twenty20 cricket tournament played in India. It was contested by 38 teams, divided into six groups, with six teams in Group A. The tournament was announced by BCCI on 3 July 2021. Maharashtra and Tamil Nadu both won four matches, with Maharashtra topping the group on net run rate. Therefore, Tamil Nadu advanced to the quarter-finals by winning their last league match against Maharashtra and the latter progressed to the preliminary quarter-finals.