A by-election for the United Kingdom parliamentary constituency of the City of Chester was held on 1 December 2022, following the resignation of incumbent member of Parliament Chris Matheson on 21 October 2022 after accusations of sexual misconduct and a recommendation from the Independent Expert Panel that he be suspended from the House of Commons for four weeks. The by-election was won by Samantha Dixon of the Labour Party. The 14-point swing was Labour's best-ever result in the seat, and the poorest result in Chester for the Conservative Party since 1832.