About: Agouti-signaling protein

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: Agouti-signaling protein Goto Sponge NotDistinct Permalink

An Entity of Type : dbo:HumanGene, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon

http://dbpedia.demo.openlinksw.com/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FAgouti-signaling_protein&invfp=IFP_OFF&sas=SAME_AS_OFF&graph=http%3A%2F%2Fdbpedia.org&graph=http%3A%2F%2Fdbpedia.org

Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. It is responsible for the distribution of melanin pigment in mammals. Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). This interaction is responsible for making distinct light and dark bands in the hairs of animals such as the agouti, which the gene is named after. In other species such as horses, agouti signalling is responsible for determining which parts of the body will be red or black. Mice with wildtype agouti will be grey, with each hair being partly yellow and partly black. Loss of function mutations in mice and other species cause black fur coloration, while m

Attributes	Values
rdf:type	Thing Biomolecule gene Biomolecule Gene HumanGene
rdfs:label	Agouti (de) Agouti-signaling protein (en) Agouti (gène) (fr) Agouti (färg) (sv) ASIP (ген) (uk) 刺鼠肽基因 (zh)
rdfs:comment	Als agouti (auch tabby oder wildfarben) bezeichnet man eine klassische Fellzeichnung. Die Bezeichnung wurde vom Namen südamerikanischer Nagetiere, den Agutis abgeleitet, bei denen die melierte Fellfärbung ebenso wie bei anderen Wildtieren eine Tarnung ermöglicht und somit einen Selektionsvorteil darstellt. Da Haustiere und Heimtiere alle von wildlebenden Artgenossen abstammen, kommt bei vielen auch die Wildfarbe „aguti“ vor, beispielsweise bei Hauskatzen, Degus, Kaninchen, Ratten, Mäusen und Meerschweinchen. Der zugehörige Genlocus, der Agouti-Locus, wurde entsprechend benannt. (de) Agouti (sigle ASIP : Agouti SIgnaling Protein) est un gène chargé de déterminer si le pelage d'un mammifère est bicolore ou d'une couleur unie (non agouti). (fr) ASIP (англ. Agouti signaling protein) – білок, який кодується однойменним геном, розташованим у людей на довгому плечі 20-ї хромосоми. Довжина поліпептидного ланцюга білка становить 132 амінокислот, а молекулярна маса — 14 515. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: Треонін V: Валін Секретований назовні. (uk) 刺鼠肽基因（英語：ASIP gene），也称Agouti基因、刺鼠基因等，是一种决定哺乳动物毛色分布的基因，通过（agouti-signaling protein，ASIP）等产物调控了哺乳动物体内天然色素、黑色素等的分布。由于在生物医学研究中的便利性，这一基因的主要机制在这些模式生物中多有研究。 (zh) Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. It is responsible for the distribution of melanin pigment in mammals. Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). This interaction is responsible for making distinct light and dark bands in the hairs of animals such as the agouti, which the gene is named after. In other species such as horses, agouti signalling is responsible for determining which parts of the body will be red or black. Mice with wildtype agouti will be grey, with each hair being partly yellow and partly black. Loss of function mutations in mice and other species cause black fur coloration, while m (en) Agouti är en pälsfärg, speciellt hos tamformer av vissa djur till exempel råtta, husmus, marsvin, ökenråtta (gerbil) och katt. Agouti är ingen bestämd färg utan avser den färg pälsen hos en vild individ har, djurets "grundfärg". Ofta skiljer sig tamformens agouti-färg från den vilda varianten till följd av avel. Exempelvis har vilda brunråttor mycket större inslag av grått i sin päls medan tamråttans agouti är mer åt det rödbruna hållet. (sv)
foaf:depiction
dcterms:subject	Mammal genes Melanocortin receptor antagonists Peptide hormones Peptides
Wikipage page ID	5509325 (xsd:integer)
Wikipage revision ID	1039488389 (xsd:integer)
Link from a Wikipage to another Wikipage	Epigenetics Melanocortin Melanocortin 1 receptor Methylation Vitamin B12 Inhibitor cystine knot Insulin resistance Melanin Melanocyte Melanocyte-stimulating hormone Genomic imprinting Gene Murinae Pigment Pheomelanin Anorexia nervosa Zinc Horse Receptor antagonist Adipocyte Agouti Agouti-related peptide Agouti (coloration) Agouti coloration genetics Mammal genes Melanocortin receptor antagonists Tumor Tumorigenesis Eumelanin Lipogenesis Lipolysis Alpha-Melanocyte-stimulating hormone Chromosome 20 Promoter (genetics) Protein Hyperinsulinemia Peptide hormones Peptides Ectopic expression Tissue (biology) Phaeomelanin Obesity Wild type Exon Trophoblast Agouti-related protein Neuroendocrine Paracrine Gene imprinting MC4R Pleiotropic Type II diabetes mellitus
Link from a Wikipage to an external page	https://deepblue.lib.umich.edu/bitstream/2027.42/75746/1/j.1749-6632.2003.tb03159.x.pdf
sameAs	Agouti-signaling protein Agouti-signaling protein Agouti-signaling protein Agouti-signaling protein Agouti-signaling protein Agouti-signaling protein Agouti-signaling protein Agouti-signaling protein Agouti-signaling protein
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Infobox_gene dbt:MeshName dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:PDBe

Faceted Search & Find service v1.17_git139 as of Feb 29 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 52 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software