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α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure and the amino acid sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. It is the most important of the melanocyte-stimulating hormones (MSHs) (also known as melanotropins) in stimulating melanogenesis, a process that in mammals (including humans) is responsible for pigmentation primarily of the hair and skin. It also plays a role in feeding behavior, energy homeostasis, sexual activity, and protection against ischemia and reperfusion injury.

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  • Alpha-Melanocyte-stimulating hormone (en)
  • Hormônio estimulante de alfa-melanócitos (pt)
  • Альфа-меланоцитстимулирующий гормон (ru)
  • Α-黑色素细胞刺激素 (zh)
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  • α-黑色素细胞刺激素(英語:α-Melanocyte-stimulating hormone,缩写为α-MSH),或称α-促黑素细胞激素、α-黑素细胞皮质激素等,是一种内源肽类激素,也是黑素皮质素家族的神经肽,有着十三肽结构,其氨基酸序列为Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2。α-黑色素细胞刺激素是最重要的黑色素细胞刺激素(MSH)之一,起到激活黑素細胞的作用;在人类在内的哺乳动物中,这一激活途径调控了毛发与皮膚等的色素分布。α-黑色素细胞刺激素也调控进食行为、能量稳态、性行为等,有着阻抑缺血、防止等保护功能。 α-黑色素细胞刺激素(α-MSH)是黑素皮质素受体MC1R、、MC4R和的完全激动剂。仅被促腎上腺皮質激素(ACTH)激活,而对α-MSH无效。MC1R的单独激活调控了毛色分布,而在MC1R调控食欲、新陈代谢、性行为时,则需要经由MC3R和MC4R。α-黑色素细胞刺激素是促腎上腺皮質激素(ACTH)分解断裂的产物,而促腎上腺皮質激素则又是前腦啡黑細胞促素皮促素(POMC)的断裂产物。 (zh)
  • α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure and the amino acid sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. It is the most important of the melanocyte-stimulating hormones (MSHs) (also known as melanotropins) in stimulating melanogenesis, a process that in mammals (including humans) is responsible for pigmentation primarily of the hair and skin. It also plays a role in feeding behavior, energy homeostasis, sexual activity, and protection against ischemia and reperfusion injury. (en)
  • Hormônio estimulante de alfa-melanócitos (alfa-MSH; α-MSH) é um hormônio peptídio da família melanocortina. É produzido no sistema nervoso central e também por células do sistema imune ou na pele e um dos seus efeitos é estimular a síntese de eumelanina. A ação do -MSH ocorre por meio de sua ligação aos receptores de melanocortinas (MC-R), expressos em diferentes células da pele, além de macrófagos, mastócitos e linfócitos T. A proteína agouti é um antagonista dos MC-R1 e MC-R4 e sua ligação a estes receptores na pele inibe a produção da eumelanina. A parte intermediária da hipófise é responsável por secretar o hormônio melanócito estimulante (MSH) em alguns animais; Sua secreção é controlada pela quantidade de luz do ambiente, onde altas quantidades de luz estimulam sua secreção e sua açã (pt)
  • α-меланоцитстимулирующий гормон, или α-меланотропин, α-мелатропин, сокращённо α-МСГ — один из представителей семейства меланоцитстимулирующих гормонов. Альфа-меланоцитстимулирующий гормон является , производимым кортикотропными клетками средней доли гипофиза в процессе расщепления проопиомеланокортина. Одновременно образуются бета-эндорфин, гамма-липотропный гормон и др. (ru)
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  • α-Melanocyte-stimulating hormone (en)
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  • α-Melanocyte-stimulating hormone (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/α-melanocyte-stimulating_hormone.svg
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