Carlos Medina Plascencia (born 14 August 1955 in León, Guanajuato) is a Mexican politician affiliated with the conservative National Action Party (PAN). He is a former mayor of León, senator and interim governor of Guanajuato (1991 – 1995). He was the President of the Chamber of Deputies in 1999. In 2005 he ran for president of the PAN but lost against Manuel Espino.