About: DNA replication stress     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Thing, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon
http://dbpedia.demo.openlinksw.com/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FDNA_replication_stress&invfp=IFP_OFF&sas=SAME_AS_OFF&graph=http%3A%2F%2Fdbpedia.org&graph=http%3A%2F%2Fdbpedia.org

DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork. There are many events that contribute to replication stress, including: * Misincorporation of ribonucleotides * Unusual DNA structures * Conflicts between replication and transcription * Insufficiency of essential replication factors * Common fragile sites * Overexpression or constitutive activation of oncogenes * Chromatin inaccessibility

AttributesValues
rdfs:label
  • DNA replication stress (en)
rdfs:comment
  • DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork. There are many events that contribute to replication stress, including: * Misincorporation of ribonucleotides * Unusual DNA structures * Conflicts between replication and transcription * Insufficiency of essential replication factors * Common fragile sites * Overexpression or constitutive activation of oncogenes * Chromatin inaccessibility (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/INO80_stabilizes_replication_forks_and_counteracts_mislocalization_of_H2A.Z.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Illustration_of_various_approaches_to_target_replication_stress_for_cancer_treatment.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Rationale_for_enhancing_replication_stress_to_kill_cancer_cells.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Replication_stress_and_its_consequences_in_mitosis.png
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
Link from a Wikipage to an external page
sameAs
dbp:wikiPageUsesTemplate
thumbnail
has abstract
  • DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork. There are many events that contribute to replication stress, including: * Misincorporation of ribonucleotides * Unusual DNA structures * Conflicts between replication and transcription * Insufficiency of essential replication factors * Common fragile sites * Overexpression or constitutive activation of oncogenes * Chromatin inaccessibility ATM and ATR are proteins that help to alleviate replication stress. Specifically, they are kinases that are recruited and activated by DNA damage. The stalled replication fork can collapse if these regulatory proteins fail to stabilize it. When this occurs, reassembly of the fork is initiated in order to repair the damaged DNA end. (en)
prov:wasDerivedFrom
page length (characters) of wiki page
foaf:isPrimaryTopicOf
is Link from a Wikipage to another Wikipage of
is Wikipage redirect of
is foaf:primaryTopic of
Faceted Search & Find service v1.17_git139 as of Feb 29 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 55 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software