David Leonard Brain (January 24, 1879 – May 25, 1959) was an infielder/outfielder in Major League Baseball who played for the Chicago White Sox (1901), St. Louis Cardinals (1903–1905), Pittsburgh Pirates (1905), Boston Beaneaters/Doves (1906–1907), Cincinnati Reds (1908) and New York Giants (1908). Brain batted and threw right-handed. He was born in Hereford, England. In a seven-season career, Brain was a .252 hitter with 27 home runs and 303 RBI in 679 games. Brain died in Los Angeles, California, at the age of 80.