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Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF2S2), and a gamma (subunit 3, EIF2S3) subunit. Once the initiation phase has completed, eIF2 is released from the ribosome bound to GDP as an inactive binary complex. To participate in another round of translation initiation, this GDP must be exchanged for GTP.

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  • EIF2 (es)
  • EIF2 (en)
  • EIF2 (pl)
  • EIF2 (pt)
  • 真核起始因子2 (zh)
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  • Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNAiMet to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF2S2), and a gamma (subunit 3, EIF2S3) subunit. Once the initiation phase has completed, eIF2 is released from the ribosome bound to GDP as an inactive binary complex. To participate in another round of translation initiation, this GDP must be exchanged for GTP. (en)
  • O fator de iniciação eucariótico 2 (eIF2) é um fator de iniciação eucariótico. Ele é necessário, em geral, para iniciação da tradução. O eIF2 medeua a ligação do tRNAmet ao ribossomo em uma maneira dependente de GTP. eIF2 é um heterotrímero, constituído de uma subunidade alfa, uma beta e uma gama (também chamadas 1, 2 e 3 respectivamente). Uma vez que a iniciação é completa, eIF2 é liberado do ribossomo ligado à GDP como um complexo binário inativo. Para participar em outra rodada de iniciação da tradução, esse GDP deve ser trocado por GTP. (pt)
  • eIF2(eukaryotic Initiation Factor 2,真核起始因子2)是一个重要的真核起始因子,它的作用是在真核翻译起始过程中介导起始tRNA(Met-tRNAi)与核糖体结合。它是一个异源三聚体,由α、β、γ三个亚基组成。eIF2也是第一个被发现的其蛋白磷酸化作用能够调控真核翻译的起始因子。 (zh)
  • eIF2 (factor de iniciación eucariota 2) es un factor de iniciación eucariótico necesario en el inicio de la traducción biológica. En este proceso fundamental de la vida, el ribosoma construye proteína s de acuerdo con la información codificada en el ARNm. El eIF2 media la unión de la tRNA reunión a los ribosomas mediante la hidrólisis de GTP. eIF2 es un heterodímero que consiste en un (también llamada subunidad 1), un (subunidad 2), un (subunidad 3) y por . * Datos: Q1017133 (es)
  • eIF2 – eukariotyczny czynnik inicjacji translacji 2 (ang. eukaryotic initiation factor 2) – białko, które bierze udział w inicjacji translacji (biosyntezy białek w komórkach). Wchodzi w skład tzw. kompleksu inicjacyjnego. Uczestniczy w wiązaniu tRNAiMet (inicjatorowego tRNA transportującego metioninę) z małą podjednostką rybosomu 40S przy udziale GTP. Składa się z trzech podjednostek: α, β i γ. (pl)
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