About: EMI domain

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In molecular biology, the EMI domain, first named after its presence in proteins of the EMILIN family, is a small cysteine-rich protein domain of around 75 amino acids. The EMI domain is most often found at the N terminus of metazoan extracellular proteins that are forming or are compatible with multimer formation. It is found in association with other domains, such as C1q, laminin-type EGF-like, collagen-like, FN3, WAP, ZP or FAS1. It has been suggested that the EMI domain could be a protein-protein interaction module, as the EMI domain of EMILIN-1 was found to interact with the C1q domain of .

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity protein yago:SocialGroup107950920 yago:Unit108189659
rdfs:label	EMI domain (en)
rdfs:comment	In molecular biology, the EMI domain, first named after its presence in proteins of the EMILIN family, is a small cysteine-rich protein domain of around 75 amino acids. The EMI domain is most often found at the N terminus of metazoan extracellular proteins that are forming or are compatible with multimer formation. It is found in association with other domains, such as C1q, laminin-type EGF-like, collagen-like, FN3, WAP, ZP or FAS1. It has been suggested that the EMI domain could be a protein-protein interaction module, as the EMI domain of EMILIN-1 was found to interact with the C1q domain of . (en)
name	EMI domain (en)
dct:subject	Protein domains
Wikipage page ID	32681132 (xsd:integer)
Wikipage revision ID	997807102 (xsd:integer)
Link from a Wikipage to another Wikipage	Caenorhabditis elegans Protein-protein interaction Proteins Molecule Vertebrate EGF-like domain Glycoproteins NEU1 Mammalia Cell (biology) Whey Acidic Protein Amino acid Cysteine Drosophila EMILIN1 Extracellular Protein domain Protein folding Protein Protein domains Fibronectin type III domain Hydrophobic Metazoan Extracellular matrix Zona pellucida-like domain TGFBI POSTN Transmembrane receptor Disulphide bonds Retroviral integration Multimer N terminus dbr:EMILIN2
sameAs	EMI domain EMI domain EMI domain
dbp:wikiPageUsesTemplate	dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist
InterPro	IPR011489 (en)
Pfam	PF07546 (en)
symbol	EMI (en)
has abstract	In molecular biology, the EMI domain, first named after its presence in proteins of the EMILIN family, is a small cysteine-rich protein domain of around 75 amino acids. The EMI domain is most often found at the N terminus of metazoan extracellular proteins that are forming or are compatible with multimer formation. It is found in association with other domains, such as C1q, laminin-type EGF-like, collagen-like, FN3, WAP, ZP or FAS1. It has been suggested that the EMI domain could be a protein-protein interaction module, as the EMI domain of EMILIN-1 was found to interact with the C1q domain of . The EMI domain possesses six highly conserved cysteine residues, which likely form disulphide bonds. Other key features of the EMI domain are the C-C-x-G-[WYFH] pattern, a hydrophobic position just preceding the first cysteine (Cys1) of the domain and a cluster of hydrophobic residues between Cys3 and Cys4. The EMI domain could be made of two sub-domains, the fold of the second one sharing similarities with the C-terminal sub-module characteristic of EGF-like domains. Proteins known to contain an EMI domain include: * Vertebrate Emilins, extracellular matrix glycoproteins. * Vertebrate Multimerins, extracellular matrix glycoproteins. * Vertebrate Emu proteins, which could interact with several different extracellular matrix components and serve to connect and integrate the function of multiple partner molecules. * Vertebrate beta-IG-H3. * Vertebrate osteoblast-specific factor 2 (OSF-2). * Mammalian NEU1/NG3 proteins. * Drosophila midline fasciclin. * Caenorhabditis elegans ced-1, a transmembrane receptor that mediates cell corpse engulfment. (en)
gold:hypernym	Domain
prov:wasDerivedFrom	wikipedia-en:EMI_domain?oldid=997807102&ns=0
page length (characters) of wiki page	3254 (xsd:nonNegativeInteger)
Symbol	EMI
foaf:isPrimaryTopicOf	wikipedia-en:EMI_domain
is Link from a Wikipage to another Wikipage of	EGFL7 EMI (disambiguation)
is Wikipage disambiguates of	EMI (disambiguation)
is foaf:primaryTopic of	wikipedia-en:EMI_domain

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