About: Egg lysin

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: Egg lysin Goto Sponge NotDistinct Permalink

An Entity of Type : yago:WikicatProteinDomains, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon

http://dbpedia.demo.openlinksw.com/c/7PPVvDAAhJ

Egg lysin is a protein that creates a hole in the envelope of the egg thereby allowing the sperm to pass through the envelope and fuse with the egg. Fertilization proteins are acrosomal proteins involved in various roles during the fertilization process. Structurally these proteins consist of a closed bundle of helices with a right-hand twist. Lysin and SP18, both characterised in abalone, are two evolutionarily related fertilization proteins that have distinctive roles.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:WikicatMembraneProteins yago:Abstraction100002137 yago:Attribute100024264 yago:Chemical114806838 yago:Compound114818238 yago:Environment113934596 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteinDomains
rdfs:label	Egg lysin (en)
rdfs:comment	Egg lysin is a protein that creates a hole in the envelope of the egg thereby allowing the sperm to pass through the envelope and fuse with the egg. Fertilization proteins are acrosomal proteins involved in various roles during the fertilization process. Structurally these proteins consist of a closed bundle of helices with a right-hand twist. Lysin and SP18, both characterised in abalone, are two evolutionarily related fertilization proteins that have distinctive roles. (en)
name	Egg lysin (en)
dct:subject	Membrane proteins Protein domains
Wikipage page ID	32046122 (xsd:integer)
Wikipage revision ID	1082976492 (xsd:integer)
Link from a Wikipage to another Wikipage	Egg (biology) Membrane proteins Abalone European Synchrotron Radiation Facility Fertilization Protein Protein domains Karolinska Institute Sperm Vitelline membrane Acrosomal
sameAs	Egg lysin Egg lysin Egg lysin Egg lysin
dbp:wikiPageUsesTemplate	dbt:InterPro_content dbt:Reflist dbt:Short_description dbt:PDB dbt:PDB3 dbt:Pfam_box
SCOP	1 (xsd:integer)
InterPro	IPR001379 (en)
Pfam	PF01303 (en)
symbol	Egg_lysin (en)
has abstract	Egg lysin is a protein that creates a hole in the envelope of the egg thereby allowing the sperm to pass through the envelope and fuse with the egg. Fertilization proteins are acrosomal proteins involved in various roles during the fertilization process. Structurally these proteins consist of a closed bundle of helices with a right-hand twist. Lysin and SP18, both characterised in abalone, are two evolutionarily related fertilization proteins that have distinctive roles. Following its release from sperm, lysin binds to the egg vitelline envelope (VE) via the VE receptor for lysin (VERL), then non-enzymatically dissolves the VE to create a hole, thereby allowing the sperm to pass through the envelope and fuse with the egg. Lysins exhibit species-specific binding to their egg receptor, possibly through differences in charged surface residues. SP18 is also released from sperm, acting as a potent fusagen of liposomes to mediate the fusion between the sperm and egg cell membranes. Despite a similarity in the overall fold, the variation in the surface features of SP18 and lysin account for their different roles in fertilization. The molecular basis of VERL-lysin interaction was revealed in June 2017 by researchers at Karolinska Institutet and ESRF, who reported X-ray crystallographic and biochemical studies of both species-specific and non-species-specific complexes between the two proteins. The corresponding 3D structures (PDB: 5MR3 and PDB: 5IIA, 5IIB), which suggest a mechanism for vitelline envelope dissolution by lysin, visualized for the first time how sperm interacts with the egg coat at the atomic level. (en)
CDD	cd00243 (en)
PDB	:22-150 B:19-150 A:19-150 B:28-150 B:19-150 (en)
gold:hypernym	Protein
prov:wasDerivedFrom	wikipedia-en:Egg_lysin?oldid=1082976492&ns=0
page length (characters) of wiki page	3691 (xsd:nonNegativeInteger)
Symbol	Egg_lysin
foaf:isPrimaryTopicOf	wikipedia-en:Egg_lysin
is Link from a Wikipage to another Wikipage of	ZP2 Lysin (disambiguation) Evidence for speciation by reinforcement Zona pellucida-like domain
is Wikipage disambiguates of	Lysin (disambiguation)
is foaf:primaryTopic of	wikipedia-en:Egg_lysin

Faceted Search & Find service v1.17_git147 as of Sep 06 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3331 as of Sep 2 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 52 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software