About: Eukaryotic initiation factor

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Eukaryotic initiation factors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the start codon and are an important input for post-transcription gene regulation. Several initiation factors form a complex with the small 40S ribosomal subunit and Met-tRNAiMet called the 43S preinitiation complex (43S PIC). Additional factors of the eIF4F complex (eIF4A, E, and G) recruit the 43S PIC to the five-prime cap structure of the mRNA, from which the 43S particle scans 5'-->3' along the mRNA to reach an AUG start codon. Recognition of the start codon by the Met-tRNAiMet promotes gated phosphate and eIF1 release to form the (48S PIC), followed by large 60S riboso

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rdf:type	yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459
rdfs:label	RNA-Helikase EIF4A (de) Eukaryotic initiation factor (en) Eukariotyczne czynniki inicjacji (pl) 真核起始因子 (zh)
rdfs:comment	真核起始因子（英文：eukaryotic initiation factor，简称为eIF），又称为真核翻译起始因子，是指参与真核翻译起始这一过程的蛋白质。与原核起始因子只有三种（IF1、IF2、IF3）相比，真核起始因子种类多且复杂，目前已鉴定的真核起始因子共有12种。通过这些真核起始因子之间以及不同的真核起始因子与核糖体、mRNA和起始tRNA之间的相互作用，来完成真核生物的翻译起始。因此相比于原核生物，真核生物的翻译起始过程更多得依赖于蛋白质与蛋白质以及蛋白质与RNA之间的相互作用，而非RNA与RNA间的相互作用。除了参与真核翻译起始进程之外，许多真核起始因子还具有其他一些功能。例如，eIF3参与细胞生长和细胞周期的调控。多个真核起始因子也与疾病相关。例如，eIF2B的两个不同亚基的编码基因的突变能够导致一种被称为“白质消失”（vanishing white matter）的严重的遗传性神经退化性疾病； eIF3的e亚基与癌症密切相关。 (zh) eIF4A (eukaryotischer Initiationsfaktor 4A) bezeichnet eine Gruppe von Proteinen, die bei der Translation von mRNA in Proteine beteiligt sind. Sie gehören zu den Initiationsfaktoren. Über die vorhandene Menge des eIF4A wird die Translation und damit die Synthese von Proteinen in der Zelle gesteuert. Die eIF4A wirken als Helikase zur Entwindung der zu übersetzenden mRNA und als ATPase. Die Energie, die für diesen Vorgang benötigt wird, wird aus der Hydrolyse von ATP gewonnen. Durch die Entwindung wird den Ribosomen erst die Anlagerung an die mRNA ermöglicht. (de) Eukaryotic initiation factors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the start codon and are an important input for post-transcription gene regulation. Several initiation factors form a complex with the small 40S ribosomal subunit and Met-tRNAiMet called the 43S preinitiation complex (43S PIC). Additional factors of the eIF4F complex (eIF4A, E, and G) recruit the 43S PIC to the five-prime cap structure of the mRNA, from which the 43S particle scans 5'-->3' along the mRNA to reach an AUG start codon. Recognition of the start codon by the Met-tRNAiMet promotes gated phosphate and eIF1 release to form the (48S PIC), followed by large 60S riboso (en) Eukariotyczne czynniki inicjacji (eIFs) to białka lub kompleksy białkowe biorące udział w inicjacji translacji u organizmów eukariotycznych. Białka te stabilizują powstawanie rybosomalnych kompleksów preninicjacyjnych wokół kodonu start i odgrywają istotną rolę w potranskrypcyjnej regulacji genów. Część czynników inicjacji translacji łączy się w kompleks z Met-tRNAiMet i małą podjednostką (40S) rybosomu - jest to kompleks preinicjacyjny 43S (43S PIC). Pozostałe czynniki tworzące kompleks eIF4F (eIF4A, E i G) przyłączają 43S PIC do czapeczki, od której następnie kompleks ten skanuje mRNA w kierunku 3' do momentu związania się z kodonem AUG. Rozpoznanie kodonu start przez tRNAiMet promuje uwolnienie czynnika , który przyłącza się do 43S PIC, formując 48S PIC. Pozwala to na dołączenie dużej p (pl)
dcterms:subject	Gene expression Molecular biology Protein biosynthesis
Wikipage page ID	9508538 (xsd:integer)
Wikipage revision ID	1078859100 (xsd:integer)
Link from a Wikipage to another Wikipage	Prokaryotic initiation factor-1 Prokaryotic initiation factor-2 MTORC1 Hypusine EIF2B EIF4A EIF4G EIF5A Internal ribosome entry site Prokaryotic initiation factors Post-transcriptional regulation MRNA Elongation factor P Protein kinase R A-site GTPase GTPase-activating protein Codon DDX3X DHX29 Helicase 43S preinitiation complex Gene expression Molecular biology Protein biosynthesis DEAD box Eukaryotic ribosome (80S) Cell signaling Protein complex Protein Guanosine diphosphate EIF1 EIF1AX EIF2A EIF2S1 EIF2S2 EIF2S3 EIF3 EIF4B EIF4E EIF4H EIF5B EIF6 DsRNA Guanine nucleotide exchange factor Poly(A)-binding protein Prokaryotic initiation factor-3 Eukaryotic initiation factor 3 Eukaryotic initiation factor 4F Eukaryotic translation Ribosome Five-prime cap RPTOR Initiation factors P-site P70-S6 Kinase 1 60S Reticulocytes TRNA Poly(A) tail 40S EIF2D EIF4F dbr:48S_preinitiation_complex
sameAs	Eukaryotic initiation factor Eukaryotic initiation factor Eukaryotic initiation factor Eukaryotic initiation factor Eukaryotic initiation factor Eukaryotic initiation factor Eukaryotic initiation factor

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