François Missoffe (13 October 1919 in Toulon, France – 28 August 2003 in Rouen) was a French politician and diplomat. He was Minister of Youth Affairs and Sport ("Ministre de la Jeunesse et des Sports") in the Government of France between 8 January 1966 and 30 May 1968. Missoffe was Ambassador to Japan from 1964 to 1966.