Francis Willoughby, 2nd Baron Middleton (4 October 1692 – 31 July 1758), was a British politician who sat in the House of Commons from 1713 to 1727. He succeeded to a barony in the Peerage of Great Britain. He was born the eldest son of Thomas Willoughby, 1st Baron Middleton, and Elizabeth, the daughter and coheiress of Sir Richard Rothwell, 1st Bt. He was the brother of Hon. Thomas Willoughby, MP. He was educated at Eton and at Jesus College, Cambridge, graduating MA in 1712. He was High Steward of the Royal Town of Sutton Coldfield from 1729.