German submarine U-221 was a Type VIIC U-boat of Nazi Germany's Kriegsmarine during World War II. Ordered on 15 August 1940 from the Germaniawerft shipyard in Kiel, she was laid down on 16 June 1941 as yard number 651, launched on 14 March 1942 and commissioned on 9 May 1942 under the command of Kapitänleutnant Hans-Hartwig Trojer. A member of twelve wolfpacks, she sank a total of Twenty one ships for a total of 69,589 gross register tons (GRT) and 759 tons in five patrols. In addition, she damaged one ship with a total tonnage of 7,197 GRT.