About: Giant-cell tumor of bone

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Giant-cell tumor of the bone (GCTOB), is a relatively uncommon tumor of the bone. It is characterized by the presence of multinucleated giant cells (osteoclast-like cells). Malignancy in giant-cell tumor is uncommon and occurs in about 2% of all cases. However, if malignant degeneration does occur, it is likely to metastasize to the lungs. Giant-cell tumors are normally benign, with unpredictable behavior. It is a heterogeneous tumor composed of three different cell populations. The giant-cell tumour stromal cells (GCTSC) constitute the neoplastic cells, which are from an osteoblastic origin and are classified based on expression of osteoblast cell markers such as alkaline phosphatase and osteocalcin. In contrast, the mononuclear histiocytic cells (MNHC) and multinucleated giant cell (MNGC

Attributes	Values
rdf:type	Thing Disease yago:Abstraction100002137 yago:Attribute100024264 yago:Condition113920835 yago:Disease114070360 yago:IllHealth114052046 yago:Illness114061805 yago:PathologicalState114051917 yago:PhysicalCondition114034177 disease yago:State100024720 umbel-rc:AilmentCondition
rdfs:label	ورم الخلايا العملاقة من العظام (ar) Riesenzelltumor (de) Giant-cell tumor of bone (en) Osteoclastoma (it) Guz olbrzymiokomórkowy kości (pl) Tumor ósseo de células gigantes (pt) Гигантоклеточная опухоль (ru)
rdfs:comment	Der Riesenzelltumor ist ein sehr seltener und prinzipiell gutartiger Tumor des Weichteilgewebes oder des Knochens, der aber lokal aggressiv wächst. Im Knochen wird er auch oft synonym als Osteoklastom bezeichnet. (de) Guz olbrzymiokomórkowy kości (łac. tumor gigantocellularis ossis, czasem niesłusznie nazywany osteoclastoma) jest rzadkim, zazwyczaj łagodnym nowotworem kości charakteryzującym się obecnością wielojądrzastych komórek olbrzymich podobnych do osteoklastów. (pl) Tumor ósseo de células gigantes (ou osteoclastoma) é um tumor ósseo relativamente incomum. É caracterizado pela presença de células gigantes multinucleadas (tipo osteoclasto). Estes tumores geralmente são benignos. Na maioria dos pacientes os tumores são de desenvolvimento lento, mas podem recorrer localmente em até 50% dos casos. As metástases para os pulmões podem ocorrer em cerca de 4% dos casos. (pt) Остеобластокластóма или гигантоклеточная опухоль — доброкачественное новообразование скелета, остеогенного происхождения. Довольно часто встречается: составляет 15—20 % всех доброкачественных опухолей костей. Чаще возникает в возрасте 20—40 лет, встречается как у мужчин, так и у женщин. Излюбленной локализацией являются трубчатые кости конечностей (главным образом нижние). В 60—70 % случаев опухоль располагается в эпифизах и эпиметафизах бедренной и большеберцовой костей. (ru) ورم الخلايا العملاقة للعظم (الاختصار بالإنجليزية: GCTOB) هو ورم غير شائع نسبياً. ويتميز بوجود خلايا عملاقة متعددة النوى (خلايا مثل ناقضة العظم). ورم الخلايا العملاقة غير شائع ويحدث في حوالي 2٪ من جميع الحالات. ومع ذلك، إذا حدث هذا النوع من الورم، فمن المرجح أن يحدث انتشار لذلك الورم إلى الرئتين. أورام الخلايا العملاقة هي عادة حميدة، مع سلوك لا يمكن التنبؤ به. وهو ورم غير متجانس يتتألف من ثلاثة خلايا مختلفة، خلايا انسجة الورم العملاقة (GCTSC) تشكل الخلايا الورمية،, تصنف الخلايا الورمية على أساس علامات الخلايا البانية مثل فوسفاتيز القلوية و أوستيوكالسين. وعلى النقيض من ذلك، تشكل الخلايا غير الورمية خلايا النسيج المنسوي وحيدات النوى (MNHC) والكسور العملاقة متعددة النوى (MNGC). وهي مشتقة من سلالة ناقضة العظم ويعبر عنها بـ سي دي 68 (بروتين) في معظم المرضى، عادة ما تكون الأورام بطيئة في التطور، (ar) Giant-cell tumor of the bone (GCTOB), is a relatively uncommon tumor of the bone. It is characterized by the presence of multinucleated giant cells (osteoclast-like cells). Malignancy in giant-cell tumor is uncommon and occurs in about 2% of all cases. However, if malignant degeneration does occur, it is likely to metastasize to the lungs. Giant-cell tumors are normally benign, with unpredictable behavior. It is a heterogeneous tumor composed of three different cell populations. The giant-cell tumour stromal cells (GCTSC) constitute the neoplastic cells, which are from an osteoblastic origin and are classified based on expression of osteoblast cell markers such as alkaline phosphatase and osteocalcin. In contrast, the mononuclear histiocytic cells (MNHC) and multinucleated giant cell (MNGC (en) L'osteoclastoma, conosciuto anche come tumore a cellule giganti, è un tumore raro che colpisce le ossa, specie le epifisi e le metafisi delle grandi ossa lunghe. Il tumore è generalmente benigno e unico, tuttavia non sono rari i casi, specialmente dopo un trattamento di radioterapia, di trasformazione (ma si può anche verificare una trasformazione spontanea del tumore) da benigna a maligna con metastasi molto diffuse ed infiltrazione delle cellule neoplastiche; in questi casi il tumore viene trattato come sarcoma. (it)
foaf:name	Giant-cell tumor of bone (en)
name	Giant-cell tumor of bone (en)
foaf:depiction
dcterms:subject	Osseous and chondromatous neoplasia
Wikipage page ID	3121384 (xsd:integer)
Wikipage revision ID	1110189115 (xsd:integer)
Link from a Wikipage to another Wikipage	MRI sequence Biopsy Bisphosphonates Denosumab Curettage Generalized signal averaging Giant cell Monoclonal antibodies Osteoclast Osteoid osteoma Aneurysmal bone cyst Apoptosis MRI contrast agent Micrograph Osseous and chondromatous neoplasia Tumor H&E stain Large cell Pathologic fracture Osteosarcoma Diagnosis Chondroblastoma Bone cyst CD68 Brown tumor Medullary cavity Giant-cell tumor of the tendon sheath Osteoblastoma Voxel Benign RANK ligand Zoledronate Multinucleated giant cells dbr:Giant-cell_reparative_granuloma
sameAs	Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone Giant-cell tumor of bone
dbp:wikiPageUsesTemplate	dbt:Citation_needed dbt:Infobox_medical_condition_(new) dbt:Medical_resources dbt:Reflist dbt:Osseous_and_chondromatous_tumors
thumbnail	wiki-commons:Special:FilePath/Giant_cell_tumour_of_bone_-_high_mag.jpg?width=300
DiseasesDB	9337 (xsd:integer)
ICD	(en) , (en) C40. (en) C41. (en)
MeshID	D018212 (en)
caption	Micrograph of a giant-cell tumor of bone showing the characteristic giant cells, H&E stain (en)
synonyms	Osteoclastoma (en)

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