About: Ibodutant

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An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
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http://dbpedia.demo.openlinksw.com/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FIbodutant&invfp=IFP_OFF&sas=SAME_AS_OFF&graph=http%3A%2F%2Fdbpedia.org&graph=http%3A%2F%2Fdbpedia.org

Ibodutant was a candidate drug for irritable bowel syndrome diarrhea, developed by The Menarini Group. As of March 2015, it underwent a multicentre double blind efficacy clinical study. Ibodutant selectively blocks the tachykinin receptor NK2, with blockade practically complete in nanomolar concentrations. A phase 2 trial in Europe (the IRIS-2 trial) completed in May 2012 with positive results. A 52-week phase 3 study was terminated as of 2015 because of low response and negative results of study NAK-06.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatNK2ReceptorAntagonists yago:Adversary109773245 yago:CausalAgent100007347 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:YagoLegalActor yago:YagoLegalActorGeo drug yago:Whole100003553 yago:WikicatTachykininReceptorAntagonists umbel-rc:DrugProduct
rdfs:label	Ibodutant (en)
rdfs:comment	Ibodutant was a candidate drug for irritable bowel syndrome diarrhea, developed by The Menarini Group. As of March 2015, it underwent a multicentre double blind efficacy clinical study. Ibodutant selectively blocks the tachykinin receptor NK2, with blockade practically complete in nanomolar concentrations. A phase 2 trial in Europe (the IRIS-2 trial) completed in May 2012 with positive results. A 52-week phase 3 study was terminated as of 2015 because of low response and negative results of study NAK-06. (en)
foaf:depiction
dcterms:subject	Cyclopentanes Piperidines NK2 receptor antagonists Tetrahydropyrans Carboxamides Benzothiazoles Tachykinin receptor antagonists
Wikipage page ID	19012257 (xsd:integer)
Wikipage revision ID	1075461677 (xsd:integer)
Link from a Wikipage to another Wikipage	Saredutant Menarini GR-159,897 Cyclopentanes Piperidines Molar concentration Clinical trial NK2 receptor antagonists Tetrahydropyrans Irritable bowel syndrome Carboxamides Benzothiazoles Nepadutant Tachykinin receptor antagonists Tachykinin receptor NK2 receptor
sameAs	Ibodutant Ibodutant Ibodutant Ibodutant Ibodutant Ibodutant
dbp:wikiPageUsesTemplate	dbt:As_of dbt:Cite_journal dbt:Drugbox dbt:Nervous-system-drug-stub dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite dbt:Neurokinin_receptor_modulators
thumbnail	wiki-commons:Special:FilePath/Ibodutant_structure.svg?width=300
ATC prefix	none (en)
c	37 (xsd:integer)
CAS number	522664 (xsd:integer)
ChemSpiderID	9702281 (xsd:integer)
H	48 (xsd:integer)
IUPAC name	Nα-[carbonyl]-N-{[1-piperidin-4-yl]methyl}-(D)-phenylalaninamide (en)
n	4 (xsd:integer)
O	4 (xsd:integer)
PubChem	11527495 (xsd:integer)
routes of administration	Oral (en)
s	1 (xsd:integer)
SMILES	CC1=CC2=CC=CCNC3CNCCNCC5CCNCC6CCOCC6 (en)
StdInChI	1 (xsd:integer)
StdInChIKey	YQYSVMKCMIUCHY-WJOKGBTCSA-N (en)
synonyms	6 (xsd:integer)
UNII	1 (xsd:integer)
Verifiedfields	changed (en)
verifiedrevid	444434892 (xsd:integer)
width	150 (xsd:integer)
has abstract	Ibodutant was a candidate drug for irritable bowel syndrome diarrhea, developed by The Menarini Group. As of March 2015, it underwent a multicentre double blind efficacy clinical study. Ibodutant selectively blocks the tachykinin receptor NK2, with blockade practically complete in nanomolar concentrations. A phase 2 trial in Europe (the IRIS-2 trial) completed in May 2012 with positive results. A 52-week phase 3 study was terminated as of 2015 because of low response and negative results of study NAK-06. (en)
IUPHAR ligand	2117 (xsd:integer)
gold:hypernym	Drug
prov:wasDerivedFrom	wikipedia-en:Ibodutant?oldid=1075461677&ns=0
page length (characters) of wiki page	3537 (xsd:nonNegativeInteger)
CAS number	522664-63-7
FDA UNII code	1H7RSQ28BJ
PubChem	11527495
foaf:isPrimaryTopicOf	wikipedia-en:Ibodutant
is Link from a Wikipage to another Wikipage of	Saredutant Menarini Tachykinin receptor 2 GR-159897 C37H48N4O4S

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