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The Membrane Attack Complex/Perforin (MACPF) superfamily, sometimes referred to as the MACPF/CDC superfamily, is named after a domain that is common to the membrane attack complex (MAC) proteins of the complement system (C6, C7, C8α, C8β and C9) and perforin (PF). Members of this protein family are pore-forming toxins (PFTs). In eukaryotes, MACPF proteins play a role in immunity and development.

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  • MACPF (de)
  • MACPF (en)
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  • MACPF ist eine Familie von Proteinen, deren Vertreter eine MACPF-Proteindomäne besitzen. MACPF-Proteine sind z. B. C6, C7, C8α, C8β und C9 des membrane attack complex (MAC) des Komplementsystems und Perforin (PF), woher die Bezeichnung stammt. Sie dienen analog zu den porenbildenden Toxinen zur Bildung einer Pore in Bakterien, Pilzen, viral infizierten und entarteten Zellen im Rahmen der Immunantwort. (de)
  • The Membrane Attack Complex/Perforin (MACPF) superfamily, sometimes referred to as the MACPF/CDC superfamily, is named after a domain that is common to the membrane attack complex (MAC) proteins of the complement system (C6, C7, C8α, C8β and C9) and perforin (PF). Members of this protein family are pore-forming toxins (PFTs). In eukaryotes, MACPF proteins play a role in immunity and development. (en)
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name
  • MAC/Perforin domain (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Crystal_structure_of_C8gamma_(green)_with_bound_peptide_from_C8alpha_(cyan).png
  • http://commons.wikimedia.org/wiki/Special:FilePath/MAC_inhibitor_CD59.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Molecular_model_of_the_pre-pore_form_of_a_MACPF_protein_based_upon_the_structure_of_pneunolysin.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/PFO_and_Plu-MACPF.png
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