Pennsylvania Route 339 (PA 339) is a 32.8-mile-long (52.8 km), north–south state highway located in Schuylkill, Columbia, and Luzerne counties in Pennsylvania. The southern terminus is at PA 54 in Mahanoy City. The northern terminus is at PA 93 in Nescopeck. The route is a two-lane road that passes through mountainous areas in the eastern part of the state. PA 339 runs north through the Coal Region to Brandonville, where it heads northwest to follow the Catawissa Creek to Mainville. From Mainville, the route passes through farmland to Mifflinville, where it follows the Susquehanna River to Nescopeck. PA 339 forms a concurrency with PA 924 in Brandonville and has an interchange with Interstate 80 (I-80) in Mifflinville.