About: Preclinical SPECT

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Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging modality for small laboratory animals (e.g. mice and rats). Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm) stimulated the development of dedicated small animal SPECT systems with sub-mm resolution. Unlike in clinics, preclinical SPECT outperforms preclinical coincidence PET in terms of resolution (best spatial resolution of SPECT - 0.25mm, PET ≈ 1 mm ) and, at the same time, allows to perform fast dynamic imaging of animals (less than 15s time frames).

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rdfs:label	Preclinical SPECT (en)
rdfs:comment	Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging modality for small laboratory animals (e.g. mice and rats). Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm) stimulated the development of dedicated small animal SPECT systems with sub-mm resolution. Unlike in clinics, preclinical SPECT outperforms preclinical coincidence PET in terms of resolution (best spatial resolution of SPECT - 0.25mm, PET ≈ 1 mm ) and, at the same time, allows to perform fast dynamic imaging of animals (less than 15s time frames). (en)
foaf:depiction
dcterms:subject	Neuroimaging Radiobiology Veterinary diagnosis 3D nuclear medical imaging
Wikipage page ID	47993602 (xsd:integer)
Wikipage revision ID	1025003629 (xsd:integer)
Link from a Wikipage to another Wikipage	Modality (medical imaging) Beta particle Pentetic acid Pertechnetate Iodine-131 Gallium 67 scan Pinhole camera SPECT Monte Carlo method MRI Magnetic resonance imaging Siemens Healthineers Medical optical imaging Mediso Bruker CT scan Gamma camera Alpha particle Neuroimaging Fluorine-18m Isotopes of bismuth Isotopes of iodine Translational research Iodine-123 Iodine-125 Isotopes of carbon Technetium-99m Thallium Radiobiology Radioactive tracer Veterinary diagnosis 3D nuclear medical imaging Photon Positron emission tomography Sodium iodide Field of view Radioisotope therapy Indium-111 Radioisotope renography Magnification Expectation–maximization algorithm Molecular imaging 99mTc Beta plus decay
sameAs	Preclinical SPECT Preclinical SPECT
dbp:wikiPageUsesTemplate	dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/High_resolution_mouse_bone_SPECT_scan.gif?width=300
has abstract	Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging modality for small laboratory animals (e.g. mice and rats). Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm) stimulated the development of dedicated small animal SPECT systems with sub-mm resolution. Unlike in clinics, preclinical SPECT outperforms preclinical coincidence PET in terms of resolution (best spatial resolution of SPECT - 0.25mm, PET ≈ 1 mm ) and, at the same time, allows to perform fast dynamic imaging of animals (less than 15s time frames). SPECT imaging requires administration of small quantities of γ-emitting radiolabeled molecules (commonly called "tracers") into the animal prior to the image acquisition. These tracers are biochemically designed in such a way that they accumulate at target locations in the body. The radiation emitted by the tracer molecules (single γ-photons) can be detected by gamma detectors and, after image reconstruction, results in a 3-dimensional image of the tracer distribution within the animal. Some key radioactive isotopes used in preclinical SPECT are 99mTc, 123I, 125I, 131I, 111In, 67Ga and 201Tl. Preclinical SPECT plays an important role in multiple areas of translational research where SPECT can be used for non-invasive imaging of radiolabeled molecules, including antibodies, peptides, and nanoparticles. Among major areas of its applications are oncology, neurology, psychiatry, cardiology, orthopedics, pharmacology and internal medicine. (en)
gold:hypernym	Radionuclide
prov:wasDerivedFrom	wikipedia-en:Preclinical_SPECT?oldid=1025003629&ns=0
page length (characters) of wiki page	23404 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Preclinical_SPECT
is Link from a Wikipage to another Wikipage of	Preclinical imaging Mediso
is foaf:primaryTopic of	wikipedia-en:Preclinical_SPECT

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