Quaker Run is a tributary of Shamokin Creek in Northumberland County, Pennsylvania, in the United States. It is approximately 3.7 miles (6.0 km) long and flows through Kulpmont, Mount Carmel Township, and Coal Township. The watershed of the stream has an area of 3.62 square miles (9.4 km2). The stream has one unnamed tributary. Quaker Run is designated as an impaired waterbody due to metals from abandoned mine drainage. Raw sewage and stormwater have also been discharged into it at times.