Roy Hampton Spencer (February 22, 1900 – February 8, 1973) was an American professional baseball catcher. He played fourteen seasons in Major League Baseball (MLB) from 1925 to 1938 for the Pittsburgh Pirates, Washington Senators, Cleveland Indians, New York Giants, and Brooklyn Dodgers. He helped the Pirates win the 1925 World Series and the 1927 National League Pennant and the Giants win the 1936 NL Pennant. He died in Port Charlotte, Florida at the age of 72.