SM UC-21 was a German Type UC II minelaying submarine or U-boat in the German Imperial Navy (German: Kaiserliche Marine) during World War I. The U-boat was ordered on 29 August 1915 and was launched on 1 April 1916. She was commissioned into the German Imperial Navy on 12 September 1916 as SM UC-21. In eleven patrols UC-21 was credited with sinking 98 ships, either by torpedo or by mines laid. They included the British hospital ship Donegal, which UC-21 torpedoed in the English Channel on 17 April 1917, killing 29 already wounded soldiers and 12 crew.