Sano Domain (佐野藩, Sano-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Shimotsuke Province (modern-day Tochigi Prefecture), Japan. It was centered in what is now part of the city of Sano, Tochigi. Sano was ruled through most of its history by a junior branch of the Hotta clan.