The Santuit Post Office is a historic post office building on Main Street in the Santuit village of Barnstable, Massachusetts. The 1+1⁄2-story wood-frame cottage was built c. 1846, and exhibits simple Gothic Revival styling reminiscent of seaside cottages that were constructed in the area between 1850 and 1875. The building served as a post office for Santuit village until the 1970s, when it was converted into a private residence. The building was listed on the National Register of Historic Places in 1987.