St James College is an independent Catholic secondary day school for boys and girls, located in Brisbane, Queensland, Australia. St James College, informally known as Jimmies, was established in 1868 with only 12 students and is the oldest Catholic boys' school in Queensland. In 1893, the Congregation of Christian Brothers agreed to take over the school following major economic depression, the government's refusal to pay staff wages and inconsistent student enrolment. As of 2021, the co-educational school had an enrolment of approximately 520 students from Year 7 to Year 12. The school principal is Anne Rebgetz.