About: Transcription factor II F

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Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes. TFIIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB.

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rdf:type	Thing Biomolecule Biomolecule Protein yago:WikicatTranscriptionFactors yago:Abstraction100002137 yago:Beginning107290905 yago:Cause107326557 yago:Chemical114806838 yago:Cognition100023271 yago:Complex105870365 yago:Compound114818238 yago:Concept105835747 yago:Content105809192 yago:Event100029378 yago:Factor107327805 yago:Happening107283608 yago:Idea105833840 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Origin107323922 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:PsychologicalFeature100023100 yago:Relation100031921 yago:YagoPermanentlyLocatedEntity protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:Whole105869584 yago:WikicatProteinComplexes yago:WikicatProteins
rdfs:label	Transkriptionsfaktor IIF (de) TFIIF (es) Transcription factor II F (en)
rdfs:comment	El factor de transcripción general IIF o TFIIF es uno de varios factores de transcripción generales que forman el complejo de pre-iniciación de la ARN polimerasa II. TFIIF está codificado por los genes GTF2F1, y . TFIIF se une a la ARN polimerasa II cuando la enzima ya no está unida a ningún otro factor de transcripción, evitando así que entre en contacto con el ADN fuera del promotor. Además, TFIIF estabiliza la ARN polimerasa II mientras está en contacto con TBP (dominio de unión a la caja TATA de TFIID) y TFIIB. (es) Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes. TFIIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB. (en) Transkriptionsfaktor IIF (TFIIF) ist ein Proteinkomplex im Zellkern von Wirbeltieren, der unentbehrlich für die Initiation der Transkription aller Gene ist. Insbesondere bindet TFIIF an die RNA-Polymerase II und stabilisiert den TFIID-TFIIA-TFIIB-Komplex und trägt so zur genauen Positionierung des Präinitiationskomplexes am Genanfang bei. Weitere Funktionen von TFIIF während der Elongationsphase sind inzwischen bekannt. (de)
foaf:name	general transcription factor IIF, polypeptide 2-like (en) general transcription factor IIF, polypeptide 2, 30kDa (en) general transcription factor IIF, polypeptide 1, 74kDa (en)
name	GTF2F1 GTF2F2 general transcription factor IIF, polypeptide 2-like (en)
dcterms:subject	Molecular genetics Proteins Gene expression Transcription factors
Wikipage page ID	12589679 (xsd:integer)
Wikipage revision ID	1079719089 (xsd:integer)
Link from a Wikipage to another Wikipage	Molecular genetics General transcription factor dbr:Transcription_factor_II_B RNA polymerase II Proteins GTF2F1 GTF2F2 Gene expression Promoter (genetics) Transcription preinitiation complex Transcription factors dbr:TATA-binding_protein Transcription factor II D Transcription factor II E Transcription factor II H Transcription factor II A
sameAs	Transcription factor II F Transcription factor II F Transcription factor II F Transcription factor II F Transcription factor II F Transcription factor II F
dbp:wikiPageUsesTemplate	dbt:Cell_signaling dbt:Gene dbt:MeshName dbt:Reflist dbt:Short_description dbt:Infobox_protein dbt:Genetics-stub dbt:Transcription_factors
OMIM	189968 (xsd:integer) 189969 (xsd:integer)
AltSymbols	TFIIF (en) TFIIF, BTF4, RAP30 (en) TFIIF, BTF4, RAP74 (en)
symbol	GTF2F1 GTF2F2 GTF2F2L (en)
UniProt	P13984 (en) P35269 (en)
has abstract	Transkriptionsfaktor IIF (TFIIF) ist ein Proteinkomplex im Zellkern von Wirbeltieren, der unentbehrlich für die Initiation der Transkription aller Gene ist. Insbesondere bindet TFIIF an die RNA-Polymerase II und stabilisiert den TFIID-TFIIA-TFIIB-Komplex und trägt so zur genauen Positionierung des Präinitiationskomplexes am Genanfang bei. Weitere Funktionen von TFIIF während der Elongationsphase sind inzwischen bekannt. TFIIF besteht aus zwei Untereinheiten (RAP74, RAP30) mit 517 und 249 Aminosäuren. Die zweite Untereinheit besitzt Helikase-Aktivität (EC 3.6.1.-). RAP74 bindet an FCP1, die für das Recycling der Polymerase notwendig ist. RAP74 interagiert außerdem mit TAF6 und RAP30 mit sowie mit . (de) El factor de transcripción general IIF o TFIIF es uno de varios factores de transcripción generales que forman el complejo de pre-iniciación de la ARN polimerasa II. TFIIF está codificado por los genes GTF2F1, y . TFIIF se une a la ARN polimerasa II cuando la enzima ya no está unida a ningún otro factor de transcripción, evitando así que entre en contacto con el ADN fuera del promotor. Además, TFIIF estabiliza la ARN polimerasa II mientras está en contacto con TBP (dominio de unión a la caja TATA de TFIID) y TFIIB. (es) Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes. TFIIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB. (en)
Arm	p (en) q (en)

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