U.S. Route 25E (US 25E) is the eastern branch of U.S. Route 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin. The road, however, continues as US 25E for roughly 2 miles (3.2 km) until it joins Interstate 75 in the Laurel County community of North Corbin at exit 29. The entire route serves as a arterial expressway for long-distance travelers and truckers connecting central Appalachia to the Great Lakes and Eastern Seaboard regions of the U.S. via access to Interstate highways.