The third USS Seneca (SP-427), later USS SP-427, was a United States Navy minesweeper and patrol vessel in commission from 1917 to 1919. Seneca was built as a civilian steam yacht in 1888 at Boston, Massachusetts. On 7 May 1917, the U.S. Navy acquired her from her owner, the , for use as a minesweeper and patrol vessel on the section patrol during World War I. She was commissioned as USS Seneca (SP-427) on 17 July 1917. Based at Tompkinsville, Staten Island, New York, Seneca carried out minesweeping and patrol duties for the rest of World War I. In 1918, she was renamed USS SP-427.