The 1899 Clemson Tigers football team represented Clemson Agricultural College—now known as Clemson University–during the 1899 Southern Intercollegiate Athletic Association football season. The Tigers completed their fourth season with a record of 4–2, with wins over Davidson, South Carolina, North Carolina A&M, and Georgia Tech and losses to Georgia and Auburn. Clemson did not host any games, but played a mix of away and neutral site games. Walter Riggs served again as coach, having also led the team in its inaugural 1896 season, while J. N. Walker was the captain.