The 1946 Muhlenberg Mules football team was an American football team that represented Muhlenberg College during the 1946 college football season. In its first season under head coach Ben Schwartzwalder, Muhlenberg compiled a 9–1 record, defeated St. Bonaventure in the Tobacco Bowl, and outscored opponents by a total of 307 to 99. The team's only loss was to Delaware by a 20–12 score. The team played its home games at Muhlenberg Field in Allentown, Pennsylvania.