The fifth edition of the Caribbean Series (Serie del Caribe) was played in 1953. It was held from February 20 through February 25, featuring the champion baseball teams of Cuba, Leones de la Habana; Panama, Chesterfield Smokers; Puerto Rico, Cangrejeros de Santurce, and Venezuela, Leones del Caracas. The format consisted of 12 games, each team facing the other teams twice. The games were played at Estadio del Cerro in Havana, the Cuban capital.