The 1964 Old Dominion 500 was a NASCAR Grand National Series event that was held on September 24, 1964, at Martinsville Speedway in Martinsville, Virginia. Forty professional stock car racing drivers would become involved in an event that would become legendary. The transition to purpose-built racecars began in the early 1960s and occurred gradually over that decade. Changes made to the sport by the late 1960s brought an end to the "strictly stock" vehicles of the 1950s.