2009–10 Serie A is the 62nd Serie A season in Unione Calcio Sampdoria's history. Sampdoria also participated in 2009–10 Coppa Italia, starting from the 3rd round. Sampdoria finished the 2008–09 Serie A season in 13th place, so they failed to qualify for any of the European competitions for the 2009–10 season. On 16 May 2010, Sampdoria finished their great season with a 1–0 win against S.S.C. Napoli, securing 4th place in 2009–10 Serie A and the final 2010–11 UEFA Champions League qualification spot.