The 2018–19 Iowa State Cyclones women's basketball team represents Iowa State University during the 2018–19 NCAA Division I women's basketball season. The Cyclones were coached by Bill Fennelly, who was in his 24th season at Iowa State. They play their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference. They finished the season 26–9, 13–5 in Big 12 play to finish in second place. They advanced to the championship game of the Big 12 women's tournament where they lost to Baylor. They received at-large bid of the NCAA women's tournament defeated New Mexico State in the first round before getting upset by Missouri State in the second round.