The 2018–19 Purdue Fort Wayne Mastodons women's basketball team represents Purdue University Fort Wayne during the 2018–19 NCAA Division I women's basketball season. The Mastodons, led by third year head coach Niecee Nelson and played their home games at play their home games at the Hilliard Gates Sports Center, with one home game at the Allen County War Memorial Coliseum. They were members of The Summit League. They finished the season 7–23, 3–13 in Summit League play to finish in eighth place. They lost in the quarterfinals of the Summit League women's tournament to South Dakota State.