The 2020–21 DePaul Blue Demons men's basketball team represented DePaul University during the 2020–21 NCAA Division I men's basketball season. They were led by sixth-year (ninth overall with DePaul) head coach Dave Leitao and played their home games at Wintrust Arena in Chicago, Illinois as members of the Big East Conference. In a season limited due to the ongoing COVID-19 pandemic, the Demons finished the season 5–14, 2–13 in Big East play to finish in last place. They defeated Providence in the first round of the Big East tournament before losing to UConn in the quarterfinals.