The 2020–21 USC Trojans men's basketball team represented the University of Southern California during the 2020–21 NCAA Division I men's basketball season. Led by eighth-year head coach Andy Enfield, they played their home games at the Galen Center in Los Angeles, California as members of the Pac-12 Conference. They finished the season 25-8, 15-5 in Pac-12 Play to finish in 2nd place. They defeated Utah in the quarterfinals of the Pac-12 tournament before losing in the semifinals to Colorado. They received an at-large bid to the NCAA tournament where they defeated Drake, Kansas, and Oregon to advance to the Elite Eight where they lost to Gonzaga.