The 2020–21 Wyoming Cowboys basketball team represented the University of Wyoming during the 2020–21 NCAA Division I men's basketball season. They were be led by Jeff Linder in his first year as head coach at Wyoming. The Cowboys played their home games at the Arena-Auditorium in Laramie, Wyoming as members of the Mountain West Conference. In a season limited due to the ongoing COVID-19 pandemic, the Cowboys finished the season 14–11, 7–9 in Mountain West play to finish in seventh place. They defeated San Jose State in the first round of the Mountain West tournament before losing to San Diego State in the quarterfinals.