The 2021–22 Mississippi State Bulldogs men's basketball team represented Mississippi State University during the 2021–22 NCAA Division I men's basketball season. The team was led by seventh-year head coach Ben Howland, and played their home games at Humphrey Coliseum in Starkville, Mississippi as a member of the Southeastern Conference. They finished the season 18–16, 8–10 in SEC play to finish 10th place. They defeated South Carolina in the second round of the SEC tournament before losing to Tennessee in the quarterfinals. They received an at-large bid to the National Invitation Tournament where they lost in the first round to Virginia.