The 2021–22 Texas Southern Tigers basketball team represented Texas Southern University during the 2021–22 NCAA Division I men's basketball season. The Tigers are led by fourth-year head coach Johnny Jones and played their home games at the Health and Physical Education Arena in Houston, Texas, as members of the West Division of the Southwestern Athletic Conference (SWAC). They finished the season 19–13, 13–5 in SWAC play to finish in second place. As the No. 2 seed, they defeated Jackson State, Grambling State, and Alcorn State to win the SWAC tournament. They received the conference’s automatic bid to the NCAA tournament as the No. 16 seed in the Midwest Region, where they defeated Texas A&M-Corpus Christi in the First Four before losing in the first round to Kansas.