The 2021–22 VMI Keydets basketball team represents the Virginia Military Institute in the 2021–22 NCAA Division I men's basketball season. The Keydets, led by seventh-year head coach Dan Earl, play their home games in Cameron Hall in Lexington, Virginia as members of the Southern Conference. They finished the regular season 16–15, 9–9 in SoCon play to finish in a tie for fifth place. As the No. 5 seed in the SoCon tournament, they lost to Wofford in the quarterfinals. They accepted an invitation to play in the College Basketball Invitational tournament marking their first postseason tournament appearance since 2014. As a No. 8 seed, they lost to No. 9-seeded UNC Wilmington in the first round.