The 2021 Pittsburgh Panthers women's soccer team represented University of Pittsburgh during the 2021 NCAA Division I women's soccer season. The Panthers were led by head coach Randy Waldrum, in his fourth season. They played home games at Ambrose Urbanic Field. This was the team's 26th season playing organized women's college soccer and their 9th playing in the Atlantic Coast Conference. The Panthers finished the season 11–7–0 overall, and 4–6–0 in ACC play to finish in ninth place. They did not qualify for the ACC Tournament and were not invited to the NCAA Tournament.