The 2021 USL League Two season is the 27th season of the USL League Two, the top pre-professional soccer league in the United States, since its establishment in 1995. The 2020 season was cancelled due to the COVID-19 pandemic. The regular season started on May 5 and concluded on July 18. 75 teams participated in this season. The Southwest Division teams elected not to play due to COVID-19 concerns.