The 2022 NASCAR Mexico Series is the fifteenth season of the NASCAR Mexico Series, a regional stock car racing series sanctioned by NASCAR in Mexico. It is the eighteenth season of the series as a NASCAR-sanctioned series. It began with the Gran Premio Nus–Kah at Súper Óvalo Chiapas on 10 April and will end with the NASCAR Puebla Gran Final at Autódromo Miguel E. Abed on 11 December. Salvador de Alba Jr. entered the season as the defending champion.