21c Museum Hotels is a contemporary art museum and boutique hotel chain based in Louisville, Kentucky. In addition to a boutique hotel, each of its nine properties features a contemporary art museum and a restaurant. It was acquired by French Hotel Group, Accor in 2018 and has locations in Lexington, Kentucky; Louisville, Kentucky; Cincinnati, Ohio; Chicago, Illinois; Bentonville, Arkansas; Durham, North Carolina; Oklahoma City, Oklahoma; Kansas City, Missouri; and Nashville, Tennessee.