The 43rd Indian Brigade was an infantry brigade of the British Indian Army that formed part of the Indian Army during the First World War. It was formed in March 1917 as part of the 16th Indian Division for service on the North West Frontier. It remained in India throughout the First World War but saw active service in the Third Anglo-Afghan War. Post-war, it was designated as 21st Indian Infantry Brigade in September 1920 and took over responsibility for the Jubbulpore Brigade Area in 1923.